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Elizabeth H. Blackburn, PhD, recipient of the 2006 Albert Lasker Award for Basic Medical Research, is Morris Herzstein Professor of Biology and Physiology in the Department of Biochemistry and Biophysics at the University of California, San Francisco. |
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(Figure A) Damaged telomeres have prevented this yeast cell from dividing. Instead, it has continuously replicated its DNA in preparation for division, resulting in numerous copies of DNA, as seen in the multiple bright spots of stained DNA. (Normal cells would display a single bright spot if their DNA were stained.) |
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(Figure B) This image dramatizes a pond microorganism cell with damaged telomeres trying, unsuccessfully, to divide. Telomeres are the last portion of chromosomes to divide. The lit up, elongated filaments shown in the cell are chromosomes that the cell is trying to pull apart. They cannot be separated because they are stuck together. |
